Listen to Why Your Weight Loss Injections Stop Working | Dr Shaw Somers

Ever feel like you’re doing everything right, but your body just stops listening? It turns out your cells might be acting like a teenager blocking out their parents’ shouting. In this deep dive, Mel Harris and guest Shaw Somers pull back the curtain on why GLP-1 medications hit a plateau and how “stupid foods” are designed to break your internal off-switch.

We’re stripping away the blame culture and looking at the hard physiology of hunger, the difference between satiety and satiation, and why your struggle with overeating is often a biological glitch rather than a lack of willpower. It’s time to stop the self-criticism and start understanding the receptors that actually run the show.

5 Key Takeaways

Receptor Down-Regulation: Flooding the body with GLP-1 hormones can cause cells to “tune out” by reducing receptors, leading to medication tolerance.

Satiety vs. Satiation: Satiety is the lasting feeling of fullness, while satiation is the process of becoming full during a meal.

The “Stupid Food” Trap: Modern processed foods are engineered to bypass our natural biological stop signals.

Biological Safeguards: Our bodies have multiple satiety signals—from stretch receptors in the stomach to taste receptors in the gut—all designed to prevent overconsumption.

Environment vs. Willpower: Constant exposure to an “inappropriate environment” makes maintaining weight loss a physiological battle, not just a mental one.

Quotes

“The more of the drug that you throw at the cells, the more they’re just turning off to it.”

“Satiety is what you feel… I am satisfied, I have satiety.”

“Humans have just wrecked it, it’s broken… we’ve totally ruined that as humans by making food so delicious, so lovely, so addictive.”

“Most of the stuff that’s available to buy in the shops now is stupid food.”

“It’s not your fault guys, you’re certainly not the only person that’s going through it.”

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Follow & Connect with Dr Shaw Somers

Dr Shaw Somers: ⁠https://www.shawsomers.com/⁠

Streamline Weightloss: ⁠https://www.streamlineweightlosssurgery.com/⁠

HOST BIO

Mel Harris is a weight loss mentor, podcast host, and founder of KIO Method Ltd, specialising in long-term weight loss maintenance after bariatric surgery and weight loss injections. After losing nearly 15 stone (90kg) following weight loss surgery in 2004, Mel has spent over 20 years navigating the realities of keeping weight off.

With lived experience of bariatric surgery, weight regain, GLP-1 medications, and metabolic health challenges, Mel is on a mission to close the gap between losing weight and keeping it off for life. Through honest, compassionate conversations, she cuts through misinformation, diet culture, and shame — offering real support, insight, and zero judgement.